methanandamide

Methanandamide is a synthetically created, stable, chiral analog of anandamide, an endogenous cannabinoid. It primarily functions as an agonist of the cannabinoid CB1 receptor, and certain stereoisomers also activate vanilloid (TRPV1) receptors. This compound has been investigated for its potential anticarcinogenic effects, including the inhibition of cancer cell invasion and the induction of apoptosis in various cancer cell lines, such as cervical, lung, glioma, and prostate cancer. Additionally, methanandamide has been studied for its role in modulating thermoregulation, demonstrating an ability to attenuate cocaine-induced hyperthermia, and its involvement in brain reward pathways, where it can act as a reinforcer of drug-taking behavior. Its enhanced metabolic stability compared to anandamide is attributed to its resistance to inactivation by fatty acid amide hydrolase (FAAH).

Other names

(R)-MethanandamideR(+)-MethanandamideR-(+)-methanandamide(R)-(+)-Arachidonyl-1'-Hydroxy-2'-PropylamideS-1 MethanandamideS1 MethanandamideS 1 MethanandamideS-2 MethanandamideS2 MethanandamideS 2 Methanandamide