Drug intelligence / Profile preview

methanesulfonyl fluoride

Development stage
Phase 1
Lead developer
Sensei Biotherapeutics
Modality
Small Molecules
01

Overview

Methanesulfonyl fluoride (MSF) is a small molecule and potent, irreversible inhibitor of acetylcholinesterase, the enzyme responsible for breaking down acetylcholine in the nervous system. By inhibiting this enzyme, MSF increases levels of acetylcholine, which can affect neurotransmission in both central and peripheral nervous systems. It has been investigated as an experimental drug for potential use in treating Alzheimer's disease due to its ability to modulate cholinergic signaling. Methanesulfonyl fluoride is highly toxic and corrosive, with significant safety hazards upon inhalation or contact with moisture; it produces toxic fumes including hydrogen fluoride and sulfur oxides when decomposed or exposed to water[1][2][3][4].

Brand names
Fumette
Other names
mesyl fluoridefluoro methyl sulfonemethanesulphonyl fluoride
02

Targets

Acetylcholinesterase

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