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methanol extraction residue of bacillus Calmette-Guérin
- Development stage
- Preclinical
- Administration
- Intradermal, Intramuscular, Subcutaneous
01
Overview
Methanol extraction residue of bacillus Calmette-Guérin (MER/BCG) is a biologic preparation derived from the Bacillus Calmette-Guérin (BCG) vaccine. BCG itself is an attenuated strain of Mycobacterium bovis used primarily as a vaccine against tuberculosis and as an intravesical immunotherapy for non-muscle invasive bladder cancer. The "methanol extraction residue" refers to a fraction obtained by extracting BCG with methanol, which retains immunostimulatory properties. This product has been investigated for its ability to stimulate the immune system and has been studied in cancer immunotherapy settings, particularly in oncology research contexts[2]. Its mechanism involves activating immune responses that can target tumor cells or infectious agents.
- Other names
- methanol extraction residue of BCGMER/BCG
02
Targets
PRR (Pattern recognition receptors)
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