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MethARO
- Development stage
- Preclinical
- Lead developer
- SafeRx Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**MethARO** is a proprietary oral, immediate-release fixed-dose combination of **methadone hydrochloride** and **disulfiram** being developed by SafeRx as an Alcohol-Resistant Opioid product. Methadone is intended to provide mu-opioid receptor agonism for opioid use disorder and/or analgesia, while disulfiram inhibits aldehyde dehydrogenase and is intended to deter alcohol consumption through an aversive alcohol-disulfiram reaction. The product uses a matrix-based tablet designed to prevent separation of its two active ingredients and is intended for opioid use disorder and moderate-to-severe pain refractory to non-opioid therapy when enforced alcohol sobriety is desired. ([saferxpharmaceuticals.com](https://saferxpharmaceuticals.com/technology/))
- Other names
- MethAROMethARO IR
02
Targets
MOR (Mu opioid receptor)ALDH1A1 (Aldehyde dehydrogenase 1 family member A1)
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