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Methionine + Vitamin B1 (also known as Methionine and Vitamin B1 for Injection) is an approved small molecule combination drug developed by Kunming Longjin Pharmaceutical. It is a fixed-dose combination consisting of the essential amino acid methionine and thiamine (Vitamin B1), typically formulated as a freeze-dried powder for injection. Methionine acts as a vital methyl donor and a precursor to glutathione, facilitating liver detoxification, supporting lipid metabolism, and protecting hepatocytes from injury. Thiamine serves as a critical cofactor for enzymes involved in carbohydrate metabolism, such as pyruvate dehydrogenase, thereby supporting energy production and the health of the nervous and digestive systems. The drug is primarily indicated for improving liver function in patients with acute and chronic hepatitis, liver cirrhosis, fatty liver, and intrahepatic cholestasis. It also serves as an adjuvant therapy for toxicities induced by alcohol, barbiturates, and sulfonamides, and provides nutritional support.
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