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Drug intelligence / Profile preview
methocarbamol + aspirin
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**Methocarbamol + aspirin** is an oral combination drug used to treat pain and muscle spasm associated with musculoskeletal disorders. **Aspirin** (a salicylate) acts as an analgesic and anti-inflammatory by irreversibly inhibiting cyclooxygenase (COX), thus reducing the production of prostaglandins involved in pain and inflammation. **Methocarbamol** is a centrally acting muscle relaxant; its mechanism is not fully established but is believed to involve general depression of the central nervous system leading to decreased muscle spasms. The combination is typically used alongside rest and physical therapy for short-term management of musculoskeletal conditions[1][3][6][8].
- Brand names
- Robaxisal
- Other names
- aspirin and methocarbamolmethocarbamol/aspirin
02
Targets
CCAAT/enhancer-binding protein beta (C/EBPβ) - COX-2 promoter interactionPGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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