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methotrexate (nanoparticle reformulation)
- Development stage
- Preclinical
- Lead developer
- Prosemble
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Oral, Intravenous, Intraarticular
01
Overview
Methotrexate (nanoparticle reformulation) is a preclinical-stage antineoplastic agent being developed by Prosemble. It consists of a nanoparticle-based delivery system for methotrexate, a small molecule inhibitor of dihydrofolate reductase (DHFR). By inhibiting DHFR, the drug prevents the conversion of dihydrofolate to tetrahydrofolate, thereby disrupting DNA synthesis and cell proliferation. The nanoparticle formulation is designed to improve the pharmacokinetic profile and tumor-specific delivery of methotrexate, potentially enhancing efficacy in leukaemia, lymphoma, and solid tumours while minimizing systemic off-target toxicities.
- Other names
- reformulated methotrexatemethotrexate nanoparticle formulation
02
Targets
TS (Thymidylate synthase)RFC1 (Reduced folate carrier type 1)DCK (Deoxycytidine kinase)FOLR1 (FRα)DHFR (Dihydrofolate reductase)
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