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methotrexate + mitomycin + vinblastine
- Development stage
- Preclinical
- Lead developer
- Pfizer
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
This is a combination chemotherapy regimen consisting of methotrexate (an antimetabolite), mitomycin (an alkylating agent), and vinblastine (a vinca alkaloid). The combination has been studied in the context of cancer treatment, particularly for advanced or metastatic malignancies. While not a standard named regimen like MVAC or M-VAC, similar combinations have been used in clinical trials for various cancers such as non-small cell lung cancer and urothelial carcinoma[1][2][4]. Each drug acts through distinct mechanisms to inhibit tumor cell proliferation and induce apoptosis.
- Other names
- methotrexate, mitomycin, vinblastine combination
02
Targets
OATP1B1 (Organic anion transporting polypeptide 1B1)TS (Thymidylate synthase)DHFR (Dihydrofolate reductase)DNATUBB (Tubulin (alpha and beta subunits))
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