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methotrexate + bleomycin + doxorubicin + cisplatin
- Development stage
- Unknown
- Lead developer
- Pfizer
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
A combination chemotherapy regimen comprising **methotrexate**, **bleomycin**, **doxorubicin**, and **cisplatin**. Each component is a small molecule antineoplastic agent with a distinct mechanism of action: methotrexate is a folate antimetabolite inhibiting dihydrofolate reductase; bleomycin is a glycopeptide antibiotic causing DNA strand breaks; doxorubicin is an anthracycline that intercalates DNA and produces free radicals; cisplatin is a platinum compound inducing DNA crosslinking. This specific four-drug combination is used primarily in the treatment of osteosarcoma.
- Other names
- MAPB
02
Targets
DNATOP2A (DNA topoisomerase II)DHFR (Dihydrofolate reductase)
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