Drug intelligence / Profile preview

methotrexate + mitomycin C + mitoxantrone + tamoxifen

Development stage
Unknown
Lead developer
Pfizer
Modality
Small Molecules
Administration
Oral, Intravenous
01

Overview

This combination involves four drugs: methotrexate, an antifolate used in chemotherapy; mitomycin C, an alkylating agent; mitoxantrone, an anthracenedione antineoplastic; and tamoxifen, a selective estrogen receptor modulator. The combination is not commonly used under a specific brand name but represents a mix of antineoplastic and hormonal therapies.

Other names
MMM + Tamoxifen3M + Tamoxifen
02

Targets

DNADHFR (Dihydrofolate reductase)ER (Estrogen receptor)TOP2A (DNA topoisomerase II)

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