methoxamine hydrochloride

Methoxamine hydrochloride is a selective alpha-1 adrenergic receptor agonist developed and marketed by Guangdong Ji-Bao Pharmaceutical. As a small molecule vasopressor, it acts by stimulating alpha-1 receptors on vascular smooth muscle, leading to potent arterial vasoconstriction and a subsequent increase in systemic vascular resistance and blood pressure. It is primarily utilized in perioperative and critical care settings to manage acute hypotension, particularly during anesthesia or spinal block. Methoxamine is notable for its lack of significant beta-adrenergic activity, which results in increased blood pressure without direct cardiac stimulation, often accompanied by a compensatory reflex bradycardia.

Other names

methoxamine