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methoxyamine hydrochloride
- Development stage
- Phase 2
- Lead developer
- TRACON Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Methoxyamine hydrochloride is the hydrochloride salt of methoxyamine and acts as a first-in-class small molecule inhibitor of the DNA base excision repair (BER) pathway. It binds to apurinic/apyrimidinic (AP) sites in DNA created during BER and stabilizes these lesions (MX-AP), thereby inhibiting the repair of cytotoxic DNA adducts induced by alkylating agents. This disruption increases cancer cell sensitivity to chemotherapy and radiation by preventing efficient repair of damaged DNA. Methoxyamine hydrochloride has been investigated primarily as an adjunct to alkylating agents in various cancers including glioblastoma and non-small cell lung cancer[2][5][8]. The drug was originally developed at Case Western Reserve University and further developed by TRACON Pharmaceuticals and the National Cancer Institute.
- Other names
- methoxyamine hydrochlorideO-methylhydroxylamine hydrochloridemethoxyammonium chloridemethoxyamine HClO-methylhydroxylammonium chlorideMAHmethylhydroxylamine hydrochloride
02
Targets
AP site (Apurinic/apyrimidinic site)
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