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methyl bacteriopurpurinimide
- Development stage
- Preclinical
- Lead developer
- Roswell Park Comprehensive Cancer Center
- Modality
- Light/Condition-Responsive Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
01
Overview
Methyl bacteriopurpurinimide is a synthetic, brain-penetrant analog of the natural product bacteriochlorin. It functions as a photosensitizer with potential applications in both tumor imaging and photodynamic therapy (PDT). After administration, it crosses the blood-brain barrier and accumulates in tumor cells. Upon exposure to near-infrared (NIR) light, it enables fluorescence-based visualization of tumors for imaging purposes and can induce cytotoxicity in tumor cells during NIR-mediated PDT. This dual action makes it a candidate for fluorescence-guided surgery and targeted antineoplastic therapy[6].
- Brand names
- Photobac
- Other names
- Methyl bacteriopurpurinimideBacteriopurpurinimide-methyl ester3-(1-Butyloxy)ethyl-3-deacetyl-bacteriopurpurin-18-n-butylimide methyl ester
02
Targets
Tumor cell lipid membrane
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