methylnissolin

Methylnissolin (also known as astrapterocarpan) is a naturally occurring isoflavonoid compound featuring a pterocarpan core structure, isolated from the roots of *Astragalus membranaceus* (Huangqi). It exhibits anti-inflammatory, antioxidant, anti-fibrotic, and anti-osteoclastogenic properties. In preclinical studies, methylnissolin has been shown to attenuate TGF-β1-induced endothelial-mesenchymal transition (EndMT) in glomerular endothelial cells, suggesting potential therapeutic utility in chronic kidney disease and renal fibrosis [1.1]. It also suppresses osteoclastogenesis and prevents postmenopausal osteoporosis by downregulating MAPK and AKT signaling pathways and activating Nrf2. Additionally, it has been investigated for its potential in regulating glucose-lipid metabolism and mitigating high glucose-induced mesangial cell proliferation.

Other names

(-)-methylnissolin(6aR,11aR)-3-hydroxy-9,10-dimethoxypterocarpan3-hydroxy-9,10-dimethoxypterocarpanastrapterocarpan