methylprednisolone + prednisone + mycophenolate mofetil

This is a combination of three immunosuppressive and anti-inflammatory drugs: methylprednisolone, prednisone, and mycophenolate mofetil. Methylprednisolone and prednisone are synthetic glucocorticoid corticosteroids that suppress inflammation and modulate immune responses by binding to the glucocorticoid receptor (NR3C1), thereby inhibiting pro-inflammatory gene expression. Mycophenolate mofetil is an immunosuppressant prodrug that inhibits inosine monophosphate dehydrogenase (IMPDH), leading to reduced guanosine nucleotide synthesis required for lymphocyte proliferation. This combination is used in various autoimmune diseases (such as lupus nephritis), organ transplantation, retroperitoneal fibrosis, Graves’ orbitopathy, idiopathic thrombocytopenic purpura (ITP), and other conditions where strong immunosuppression is needed[1][2][3][5][6][7].

Brand names

Depo-Medrol

Other names

none