methylprednisolone acetate

Methylprednisolone acetate is a synthetic glucocorticoid corticosteroid with potent anti-inflammatory and immunosuppressive properties. In the clinical trial context provided by LifeMark Health (NCT01183598), it is administered as a single 80mg intra-articular injection mixed with 1% lidocaine for the treatment of symptomatic knee osteoarthritis. The methylprednisolone component acts as an agonist at the glucocorticoid receptor, modulating gene expression to inhibit the production of pro-inflammatory cytokines and enzymes. The lidocaine component, a local anesthetic, provides immediate analgesia by blocking voltage-gated sodium channels in neuronal membranes. This combination is designed to provide both rapid-onset and sustained symptomatic relief from joint pain and inflammation associated with osteoarthritis.

Brand names

Depo-Medrol

Other names

Methylprednisolone acetate + lidocaineMethylprednisolone (Corticosteroid)