Drug intelligence / Profile preview

Metmose-GV23

Development stage
Unknown
Lead developer
Biomax Biotechnics
Modality
Small Molecules
Administration
Oral
01

Overview

Metmose-GV23 is a fixed-dose combination oral anti-diabetic medication marketed by Biomax Biotechnics for the management of Type 2 diabetes mellitus. It combines three active ingredients with distinct and complementary mechanisms of action to achieve optimal glycemic control. Metformin hydrochloride, a biguanide, primarily reduces hepatic glucose production and improves peripheral insulin sensitivity. Glimepiride, a second-generation sulfonylurea, stimulates insulin secretion from pancreatic beta cells by binding to the sulfonylurea receptor 1 (SUR1) component of ATP-sensitive potassium channels. Voglibose, an alpha-glucosidase inhibitor, delays the digestion and absorption of carbohydrates in the small intestine, thereby reducing postprandial blood glucose spikes. This triple therapy is typically indicated for patients whose blood glucose levels are not adequately controlled by dual therapy with metformin and a sulfonylurea.

Brand names
Metmose-GV23Metmose-GV-23Metmose-GV 23
Other names
Metformin HCL + Glimepiride + Voglibose TabletsMetformin + Glimepiride + Voglibose
02

Targets

AMPK (Adenosine monophosphate–activated protein kinase)KATP channel (ATP-sensitive potassium channel)ND1 (Mitochondrial electron transport chain complex I)Sucrase-Isomaltase

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