metoclopramide + dexketoprofen trometamol

Metoclopramide + dexketoprofen trometamol is a fixed-dose combination of two active pharmaceutical ingredients used primarily for the acute treatment of migraine and other types of moderate to severe pain. Metoclopramide is a dopamine D2 receptor antagonist with antiemetic and prokinetic properties, commonly used to treat nausea, vomiting, and gastroparesis. Dexketoprofen trometamol is the tromethamine salt form of dexketoprofen, an NSAID (non-steroidal anti-inflammatory drug) that inhibits cyclooxygenase (COX-1 and COX-2), reducing prostaglandin synthesis to provide analgesic, anti-inflammatory, and antipyretic effects. The combination leverages metoclopramide’s ability to control nausea often associated with migraine or pain therapy while enhancing analgesia through dexketoprofen’s action[2][4][6].