Drug intelligence / Profile preview

metoprolol + diltiazem

Development stage
Discontinued
Lead developer
US Pharmaceuticals Holdings I
Modality
Small Molecules
Administration
Oral, Intravenous
01

Overview

This is a combination of two cardiovascular medications - metoprolol (a beta-blocker) and diltiazem (a calcium channel blocker). While both drugs are individually used to treat conditions like hypertension and atrial fibrillation, their combination is generally approached with caution due to potentially serious drug interactions. The combination can cause enhanced negative effects on heart rate, blood pressure, and cardiac conduction, potentially leading to bradycardia, hypotension, heart block, or heart failure.

02

Targets

ADRB1 (β1)LTCC (Voltage-gated calcium channel (L-type))

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