metronidazole + mezlocillin

Metronidazole + mezlocillin is a combination of two antibiotics used primarily for the treatment and prophylaxis of mixed aerobic and anaerobic bacterial infections, especially in surgical settings such as colon surgery. Metronidazole is a nitroimidazole antibiotic effective against anaerobic bacteria and certain protozoa by disrupting DNA synthesis. Mezlocillin is an extended-spectrum penicillin (antipseudomonal penicillin) that inhibits bacterial cell wall synthesis, targeting a broad range of Gram-negative and some Gram-positive organisms. The combination provides synergistic activity against both facultative and obligate anaerobes, including Enterococci, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Bacteroides species, Clostridium species, Fusobacterium species, Peptococcus and Peptostreptococcus[1][2][3][6]. This regimen is often used for perioperative prophylaxis in abdominal surgeries to reduce postoperative infection rates[2].

Other names

metronidazole plus mezlocillinmetronidazole/mezlocillin