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mezigdomide + elranatamab
- Development stage
- Phase 2
- Lead developer
- Bristol Myers Squibb
- Modality
- T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Molecular Glues → Targeted Protein Degraders (TPDs) → Small Molecules, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Oral, Subcutaneous
01
Overview
Mezigdomide + elranatamab is a combination therapy being developed by Bristol Myers Squibb for the treatment of relapsed/refractory multiple myeloma (RRMM). The regimen consists of mezigdomide, an oral Cereblon E3 Ligase Modulator (CELMoD), and elranatamab, a bispecific T-cell engager targeting B-cell maturation antigen (BCMA) and CD3. Mezigdomide acts as a molecular glue that binds to the Cereblon E3 ligase complex, facilitating the recruitment and subsequent proteasomal degradation of the transcription factors Ikaros (IKZF1) and Aiolos (IKZF3). This degradation leads to direct apoptosis of myeloma cells and stimulates immune effector cells. Elranatamab (marketed as Elrexfio) simultaneously binds to BCMA on the surface of multiple myeloma cells and CD3 on T-cells, bridging them to induce T-cell mediated cytotoxicity. The combination is currently being evaluated in the Phase 1b/2a MELT-MM clinical trial (NCT06645678) to establish the recommended dose and assess preliminary efficacy in patients who have received multiple prior lines of therapy.
- Other names
- mezigdomide plus elranatamab
02
Targets
BCMA (B-cell maturation antigen)CD3 (T-cell surface glycoprotein CD3)CRBN (Cereblon)IKZF1 (Ikaros family zinc finger protein 1)IKZF3 (Zinc finger protein Aiolos)
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