mezlocillin

Mezlocillin is a broad-spectrum semisynthetic penicillin antibiotic of the ureidopenicillin subclass. It is derived from ampicillin and was developed by Bayer. Mezlocillin acts by binding to penicillin-binding proteins (PBPs) in bacterial cell walls, inhibiting the final stage of peptidoglycan synthesis and leading to cell lysis. It is active against a wide range of Gram-negative bacteria (including *Pseudomonas aeruginosa*, *Escherichia coli*, *Klebsiella* species) as well as some Gram-positive organisms. Unlike most extended-spectrum penicillins, it is primarily excreted via the liver and thus useful for biliary tract infections such as ascending cholangitis. Mezlocillin was administered intravenously or intramuscularly due to poor oral absorption and has been discontinued in the United States[1][2][5].

Brand names

MezlinBAYPEN

Other names

mezlocillin sodium