mezlocillin + netilmicin

Mezlocillin + netilmicin is a fixed-dose combination of two antibiotics used primarily for the prophylaxis and treatment of serious bacterial infections, especially in surgical settings such as cardiac pacemaker implantation[1][2]. Mezlocillin is an extended-spectrum penicillin (beta-lactam antibiotic) that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis[3][8][10]. Netilmicin is an aminoglycoside antibiotic that binds irreversibly to the 30S ribosomal subunit of bacteria, interfering with protein synthesis by causing misreading of mRNA and production of nonfunctional or toxic peptides[4][6]. The combination provides broad-spectrum coverage against both Gram-positive and Gram-negative bacteria, including strains resistant to other antibiotics. This synergistic effect makes it particularly useful for preventing infections caused by methicillin-resistant staphylococci and other difficult-to-treat organisms in high-risk surgical procedures[1][5].

Other names

mezlocillin-netilmicin combinationmezlocillin and netilmicin