Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
mFOLFOXIRI + cadonilimab + fruquintinib
- Development stage
- Phase 2
- Lead developer
- Sun Yat-sen University
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
mFOLFOXIRI + cadonilimab + fruquintinib is an investigational combination neoadjuvant therapy regimen being evaluated for the treatment of locally advanced colorectal cancer (LARC). The regimen integrates the intensive chemotherapy backbone mFOLFOXIRI (modified folinic acid, 5-fluorouracil, oxaliplatin, and irinotecan) with cadonilimab (AK104), a bispecific antibody targeting both PD-1 and CTLA-4, and fruquintinib, a highly selective small molecule inhibitor of VEGFR-1, -2, and -3. This multi-modal approach is designed to enhance anti-tumor activity through simultaneous cytotoxic action, dual checkpoint inhibition to overcome immune evasion, and inhibition of tumor angiogenesis. It is currently being studied in the Phase II OPTICAL-2 trial (NCT05571644) led by Sun Yat-sen University to improve pathological complete response rates and surgical outcomes in LARC patients.
- Brand names
- Kaitanni
- Other names
- mFOLFOXIRI + AK104 + fruquintinibmodified FOLFOXIRI plus cadonilimab and fruquintinib
02
Targets
CTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)DNATOP1 (DNA Topoisomerase I)PDCD1 (Programmed cell death protein 1 receptor)TS (Thymidylate synthase)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)
Beyond the preview
Go deeper on mFOLFOXIRI + cadonilimab + fruquintinib.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on mFOLFOXIRI + cadonilimab + fruquintinib.