Drug intelligence / Profile preview

MG01-T521

Development stage
Unknown
Lead developer
Inmunotek
Modality
Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Subcutaneous
01

Overview

**MG01-T521** is an investigational subcutaneous allergen immunotherapy developed by Inmunotek for patients sensitized to both grass and Cupressaceae pollens. It is a pharmaceutically single, heterogeneous mixture of polymerized allergenic extracts comprising MG01 grass-pollen extract and T521 Cupressaceae-pollen extract. Repeated subcutaneous administration is intended to induce allergen-specific immune tolerance and reduce IgE-mediated respiratory allergy symptoms and rescue-medication use in allergic rhinitis or rhinoconjunctivitis, including in patients with concomitant mild to moderate allergic asthma. The Phase 3 program includes a randomized, double-blind, placebo-controlled multicenter Spanish study evaluating subcutaneous treatment of allergy to Cupressaceae and grasses. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04898283))

Other names
MG01 + T521
02

Targets

sIgG4 (Allergen-specific immunoglobulin G4)TCR (T cell antigen receptor complex)

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