Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
mGlu8 positive allosteric modulator
- Development stage
- Preclinical
- Lead developer
- Vanderbilt University
- Modality
- Small Molecules
01
Overview
The mGlu8 positive allosteric modulator (PAM) is a small molecule therapeutic candidate developed by the Warren Center for Neuroscience Drug Discovery (WCNDD) for the treatment of Parkinson's disease. As a positive allosteric modulator of the metabotropic glutamate receptor 8 (mGlu8), it enhances the activity of this Group III metabotropic glutamate receptor. mGlu8 is primarily located presynaptically in the central nervous system, where it acts as an autoreceptor to regulate glutamate release. By modulating mGlu8 activity, the drug aims to restore neurotransmitter balance and provide neuroprotective or symptomatic benefits in neurodegenerative conditions. The program is currently in the preclinical stage of development.
- Other names
- metabotropic glutamate receptor 8 positive allosteric modulator
02
Targets
GRM8 (mGluR8)GRM7 (mGluR7)GRM4 (mGluR4)
Beyond the preview
Go deeper on mGlu8 positive allosteric modulator.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on mGlu8 positive allosteric modulator.