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mGluR5 negative allosteric modulator
- Development stage
- Preclinical
- Lead developer
- Hua Medicine
- Modality
- Small Molecules
- Administration
- Intraperitoneal, Oral, Intravenous, Subcutaneous
01
Overview
mGluR5 negative allosteric modulator is a small molecule drug candidate being developed by Hua Medicine. It functions as a negative allosteric modulator (NAM) of the metabotropic glutamate receptor 5 (mGluR5), a G protein-coupled receptor that plays a key role in modulating excitatory neurotransmission in the central nervous system. The drug is primarily targeted for the treatment of Parkinson's Disease Levodopa-Induced Dyskinesia (PD-LID) and drug addiction. By acting as a negative allosteric modulator, the compound binds to a site distinct from the orthosteric glutamate binding site to reduce receptor activity. This mechanism is intended to alleviate the motor complications associated with long-term levodopa therapy in Parkinson's patients and to modulate the neurobiological pathways involved in substance use disorders.
- Other names
- mGluR5 negative allosteric modulatormGluR-5 negative allosteric modulatormGluR 5 negative allosteric modulator
02
Targets
GRM5 (Metabotropic glutamate receptor 5)
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