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MGT-007
- Development stage
- Unknown
- Lead developer
- Metagen Therapeutics
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Rectal
01
Overview
MGT-007 is an investigational fecal microbiota transplantation (FMT) therapy developed by Metagen Therapeutics. It is designed to modulate the gut microbiome to enhance the efficacy of immune checkpoint inhibitors in patients with gastrointestinal cancers. The therapy is administered via colonoscopy and is currently being evaluated in exploratory clinical research in collaboration with the National Cancer Center and Juntendo University. By restoring or altering the microbial composition of the gut, MGT-007 aims to overcome resistance to immunotherapy and improve clinical outcomes for cancer patients.
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