MI2

MI2 (also known as MI-2) is a small molecule inhibitor of the paracaspase MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1). It functions by covalently and irreversibly binding to the MALT1 protease domain, which blocks the cleavage of key substrates such as BCL10, CYLD, and RelB. This action effectively inhibits the activation of the NF-κB signaling pathway, a driver of cell survival and proliferation in various B-cell malignancies and acute myeloid leukemia (AML). Developed primarily as a research tool and chemical probe, MI2 has shown significant anti-leukemic and anti-lymphoma activity in preclinical models, particularly in activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL).

Other names

MALT1 inhibitor MI2MALT-1 inhibitor MI2MALT 1 inhibitor MI2