mianserin hydrochloride

Mianserin hydrochloride is a tetracyclic antidepressant (TeCA) belonging to the piperazino-azepine group. Unlike traditional tricyclic antidepressants or SSRIs, it does not significantly inhibit the reuptake of serotonin or norepinephrine. Its primary therapeutic effect is mediated through the blockade of presynaptic alpha-2 adrenergic receptors, which enhances noradrenergic neurotransmission by increasing the release of norepinephrine. Additionally, it acts as a potent antagonist at 5-HT2A, 5-HT2C, 5-HT3, and 5-HT7 serotonin receptors, as well as the H1 histamine receptor. The H1 antagonism is responsible for its significant sedative properties, making it useful for depressed patients with insomnia. Originally developed by Organon and marketed under brand names like Tetramide and Tolvon, it is approved in many countries for the treatment of depressive disorders, although it was never introduced in the United States due to concerns regarding agranulocytosis.

Brand names

TetramideTolvonBolvidonNorvalLantanon

Other names

mianserin hydrochloridemianserin HCl