micafungin

Micafungin is a semisynthetic lipopeptide antifungal agent of the echinocandin class. It is used for the treatment and prevention of various Candida infections, including candidemia (fungal infection in the blood), acute disseminated candidiasis, esophageal candidiasis (infection of the throat), candida peritonitis and abscesses (infection in the abdomen), and as prophylaxis against Candida infections in patients undergoing hematopoietic stem cell transplantation. Micafungin acts by inhibiting beta‑1,3‑D‑glucan synthase—an enzyme essential for fungal cell wall synthesis—leading to disruption of fungal cell wall integrity and ultimately fungal death. It is fungicidal against some Candida species but generally fungistatic against Aspergillus species[1][2][7].

Brand names

Mycamine

Other names

micafunginemicafunginumMicafunginaPneumocandin A0, 1-((4R,5R)-4,5-dihydroxy-N2-(4-(5-(4-(pentyloxy)phenyl)-3-isoxazolyl)benzoyl]-L-ornithine)-4-((4S)-4-hydroxy-4-(4-hydroxy-3-(sulfooxy)phenyl)-L-threonine)