miconazole

Miconazole is a synthetic imidazole antifungal agent used to treat a variety of fungal infections, including those affecting the skin (such as athlete's foot, jock itch, and ringworm), vagina (vulvovaginal candidiasis), and mouth (oropharyngeal candidiasis)[1][2][3][4][5]. It is available in multiple topical and intravaginal formulations. Miconazole acts primarily by inhibiting the fungal enzyme 14α-lanosterol demethylase, a key component of the CYP450 complex. This inhibition disrupts ergosterol synthesis, leading to altered cell membrane composition and increased permeability, which results in leakage of cellular contents and ultimately inhibits fungal growth[3][5][6]. Miconazole also exhibits some activity against Gram-positive bacteria[3]. The drug was first synthesized in 1969 and received FDA approval in 1974. It is minimally absorbed systemically when applied topically but can be absorbed through mucosal surfaces[5].

Brand names

MonistatAloe Vesta Clear AntifungalAzolenBaza AntifungalCritic-Aid Clear AFCruex Prescription Strength

Other names

miconazole nitrate