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miconazole + hydrocortisone
- Development stage
- Phase 4
- Lead developer
- Johnson & Johnson
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Topical
01
Overview
Miconazole + hydrocortisone is a topical combination drug used primarily to treat skin infections, including irritant diaper dermatitis and other fungal skin conditions. It combines miconazole, an imidazole antifungal that inhibits the enzyme CYP450 14α-lanosterol demethylase in fungi, disrupting ergosterol synthesis and compromising cell membrane integrity, with hydrocortisone, a corticosteroid that reduces inflammation by suppressing leukocyte migration and reversing increased capillary permeability. The combination provides both antifungal action (from miconazole) and anti-inflammatory relief (from hydrocortisone), leading to rapid symptomatic improvement in pruritus and inflammation associated with dermatophyte or yeast infections[1][5][8].
- Brand names
- DaktacortDaktodorCortimycBrentacort
- Other names
- hydrocortisone/miconazole
02
Targets
CYP51A1 (Sterol 14α-demethylase)GR (Glucocorticoid receptor)
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