miconazole + hydrocortisone

Miconazole + hydrocortisone is a topical combination drug used primarily to treat skin infections, including irritant diaper dermatitis and other fungal skin conditions. It combines miconazole, an imidazole antifungal that inhibits the enzyme CYP450 14α-lanosterol demethylase in fungi, disrupting ergosterol synthesis and compromising cell membrane integrity, with hydrocortisone, a corticosteroid that reduces inflammation by suppressing leukocyte migration and reversing increased capillary permeability. The combination provides both antifungal action (from miconazole) and anti-inflammatory relief (from hydrocortisone), leading to rapid symptomatic improvement in pruritus and inflammation associated with dermatophyte or yeast infections[1][5][8].

Brand names

DaktacortDaktodorCortimycBrentacort

Other names

hydrocortisone/miconazole