Drug intelligence / Profile preview

Micralax

Development stage
Unknown
Lead developer
Buckinghamshire Healthcare NHS Trust
Modality
Small Molecules
Administration
Rectal
01

Overview

Micralax is a brand-name rectal micro-enema used as a stimulant and osmotic laxative for the management of constipation and for bowel cleansing prior to rectal examinations or surgery. It consists of a combination of sodium citrate, sodium lauryl sulfoacetate, and sorbitol. Sodium citrate and sorbitol act as osmotic agents, drawing water into the lower bowel to soften the stool, while sodium lauryl sulfoacetate acts as a wetting agent (surfactant) to facilitate water penetration into hard fecal matter. The formulation acts locally within the rectum to stimulate the defecation reflex, typically producing results within 5 to 15 minutes. In clinical research, such as the Phase 4 trial conducted by Buckinghamshire Hospitals NHS Trust, Micralax has been evaluated for its efficacy in managing neurogenic bowel dysfunction in patients with chronic spinal cord injury.

Brand names
Micralax
Other names
sodium citrate micro-enema

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