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microbial transplant therapy

Development stage: Phase 1
Lead developer: Intermountain Health
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

Microbial Transplant Therapy (MTT) is an investigational biologic therapy being evaluated by Dr. Joshua Stern at Intermountain Healthcare for the treatment of recurrent kidney stones. It is administered as oral capsules containing a whole community of gut microbiota derived from fecal material. The therapy is designed to modify the gut microbiome's composition, which in turn alters urinary chemistry parameters like calcium and oxalate. This modulation of intestinal metabolism is intended to reduce the risk factors for the formation of calcium-oxalate kidney stones. An early Phase 1 clinical trial (NCT05516472) is assessing the therapy's impact on urine parameters in patients with hypercalciuria and hyperoxaluria who have a history of producing at least 50% calcium-oxalate stones.

Other names: fecal microbiota transplant

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