micronized palmitoylethanolamide + ultra-micronized palmitoylethanolamide

This is a **combination formulation** that contains both micronized and ultra-micronized forms of **palmitoylethanolamide** (PEA), an endogenous fatty acid amide with documented anti-inflammatory, analgesic, immunomodulatory, and neuroprotective effects. Both forms increase the bioavailability and absorption of PEA, aiming to enhance efficacy for chronic pain and inflammation management. PEA acts by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-α), and modulates other targets such as G protein-coupled receptor 55 (GPR55), G protein-coupled receptor 119 (GPR119), and transient receptor potential vanilloid receptor 1 (TRPV1). It also inhibits mast cell activation, offering both central and peripheral pain relief, with established clinical application especially in neuropathic pain and musculoskeletal disorders. The micronized and ultra-micronized formulations are designed for improved oral uptake, addressing PEA's naturally poor bioavailability[3][5].

Brand names

Normast MPS

Other names

micronized and ultra-micronized PalmitoylethanolamidemPEA + umPEAPEA-m + PEA-um