microRNA-1275 mimic

microRNA-1275 mimic is a synthetic double-stranded RNA molecule designed to replicate the biological activity of endogenous microRNA-1275 (miR-1275). In the context of oncology, particularly hepatocellular carcinoma (HCC), miR-1275 acts as a tumor suppressor that is frequently downregulated. The mimic functions by binding to the 3' untranslated region (UTR) of target messenger RNAs, most notably Eukaryotic translation initiation factor 5A-2 (EIF5A2), leading to translational repression or mRNA degradation. By silencing EIF5A2, the mimic inhibits the downstream PI3K/Akt signaling pathway, which effectively restricts the epithelial-mesenchymal transition (EMT), cell stemness, proliferation, migration, and metastasis of cancer cells. Research has also indicated that its antitumor effects can be synergistically enhanced when used in combination with genistein.

Other names

microRNA-1275 mimicmicroRNA1275 mimicmicroRNA 1275 mimicmiR-1275 mimicmiR1275 mimicmiR 1275 mimic