microRNA-128

microRNA-128 (miR-128) is a tumor-suppressive microRNA that is frequently downregulated in various malignancies, most notably glioblastoma multiforme (GBM). It plays a critical role in regulating the self-renewal of glioblastoma stem-like cells (GSCs) and modulating the proneural-to-mesenchymal transition (PMT), a process associated with increased malignancy and therapy resistance. miR-128 exerts its effects by post-transcriptionally targeting components of the Polycomb Repressor Complexes (PRC), specifically BMI1 (a component of PRC1) and SUZ12 (a component of PRC2). By inhibiting these targets, miR-128 suppresses their epigenetic activity, including the ubiquitination of H2AK119 and tri-methylation of H3K27. Research conducted at Brigham and Women's Hospital and Harvard Medical School has demonstrated that restoring miR-128 levels can sensitize GSCs to irradiation and inhibit tumor growth in intracranial glioblastoma models.

Other names

miR-128-1miR128-1miR 128-1miR-128-2miR128-2miR 128-2miR-128-3pmiR128-3pmiR 128-3pmiR-128-5pmiR128-5pmiR 128-5phsa-miR-128hsa-miR128hsa-miR 128