microRNA-133b enriched exosomes

MicroRNA-133b enriched exosomes are experimental therapeutic exosome-based biologics derived from multipotent mesenchymal stromal cells (MSCs) that have been genetically modified to overexpress microRNA-133b (miR-133b). These 30-100 nm membrane vesicles serve as delivery vehicles for miR-133b, a small non-coding RNA that regulates gene expression post-transcriptionally. In preclinical models of neurological injury, such as stroke, spinal cord injury, and intracerebral hemorrhage, these exosomes have demonstrated neuroprotective and regenerative effects. The mechanism involves the downregulation of biological targets including Ras homolog gene family member A (RhoA) and connective tissue growth factor (CTGF), which in turn promotes neural plasticity, neurite remodeling, and functional recovery. Typically administered systemically via intravenous or intra-arterial injection, this modality represents a cell-derived biologic approach to treating central nervous system disorders.

Other names

miR-133b enriched exosomesmiR133b enriched exosomesmiR 133b enriched exosomesmiR-133b-MSCs-ExomiR133b-MSCs-ExomiR 133b-MSCs-ExoMSC-derived miR-133b enriched exosomes