microRNA-200c

microRNA-200c (miR-200c) is a member of the miR-200 family and acts as a master regulator of the epithelial phenotype. It functions primarily as a tumor suppressor by inhibiting the expression of transcription factors such as ZEB1 and ZEB2, which are critical drivers of epithelial-to-mesenchymal transition (EMT). In aggressive cancers like triple-negative breast cancer (TNBC), miR-200c is often downregulated, and its restoration has been shown to suppress tumor growth and metastasis. Beyond its direct effects on tumor cells, miR-200c modulates the tumor microenvironment by inducing a cytokine profile (including the upregulation of GM-CSF) that promotes the polarization of macrophages toward an antitumor M1 phenotype. While currently in the preclinical stage of development, miR-200c mimics represent a potential RNA-based therapeutic strategy for treating metastatic and immune-suppressive cancers.

Other names

miR-200c-3pmiR200c-3pmiR 200c-3pmicroRNA 200cmicroRNA200cmicroRNA-200c