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microRNA-338-3p mimic
- Development stage
- Preclinical
- Modality
- MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
A microRNA-338-3p mimic is a synthetic double-stranded RNA oligonucleotide designed to replicate the biological activity of endogenous miR-338-3p. In the context of hepatocellular carcinoma (HCC), miR-338-3p acts as a tumor suppressor by directly targeting the transcription factor SOX4. Overexpression of miR-338-3p via mimics has been shown to inhibit the self-renewal of liver cancer stem cells (CSCs), suppress tumorigenesis, and enhance the sensitivity of HCC cells to lenvatinib-induced apoptosis. It is primarily utilized in preclinical research to investigate miRNA-mediated gene regulation and as a potential therapeutic strategy for liver cancer.
- Other names
- miR-338-3p mimicmiR338-3p mimicmiR 338-3p mimichsa-miR-338-3p mimichsa-miR338-3p mimichsa-miR 338-3p mimic
02
Targets
Activator of HSP90 ATPase 1 mRNA 3'-untranslated region (AHSA1 mRNA 3'-UTR)A-kinase anchoring protein 12 (AKAP12) messenger RNA 3'-untranslated regionSOX4 (SRY-box transcription factor 4)
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