midazolam + cabotegravir

Midazolam is a benzodiazepine used to produce sedation, relieve anxiety, and induce amnesia before medical procedures or surgery. It acts by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor in the central nervous system, resulting in sedative, anxiolytic, muscle relaxant, and anticonvulsant effects[3][8]. Cabotegravir (GSK1265744) is an HIV integrase strand transfer inhibitor (INSTI) developed for both oral and long-acting injectable use for treatment and prevention of HIV infection. It inhibits HIV replication by blocking the integration of viral DNA into host cell DNA. Cabotegravir has a high barrier to resistance and does not require pharmacokinetic boosting[1][4][5]. The combination "midazolam + GSK1265744" refers to co-administration rather than a fixed-dose combination; studies have shown no clinically significant interaction between these drugs[1][2].

Brand names

VersedVocabriaCabenuva

Other names

midazolamcabotegravir