midazolam + etomidate

Midazolam + etomidate is a combination of two intravenous anesthetic agents used primarily for procedural sedation and induction of anesthesia. Midazolam is a short-acting benzodiazepine that acts as a positive allosteric modulator at the gamma-aminobutyric acid type A (GABA-A) receptor, producing anxiolytic, amnestic, muscle relaxant, and sedative effects. Etomidate is an imidazole derivative anesthetic that also acts on the GABA-A receptor to induce hypnosis with minimal cardiovascular depression. The combination leverages the rapid onset and hemodynamic stability of etomidate with the anxiolytic and amnestic properties of midazolam. This pairing can provide effective sedation while minimizing adverse hemodynamic changes during procedures[1][2][3][4][7].

Other names

咪达唑仑复合依托咪酯