Drug intelligence / Profile preview

Midol

Development stage
Unknown
Lead developer
Bayer
Modality
Small Molecules
Administration
Oral
01

Overview

Midol is a brand of over-the-counter (OTC) combination medications primarily marketed for the relief of symptoms associated with premenstrual syndrome (PMS) and menstruation, such as cramps, bloating, fatigue, headache, and backache. The specific active ingredients in Midol formulations have varied over time and across different sub-brands. Common formulations include combinations of analgesics (like acetaminophen, aspirin, ibuprofen, or naproxen sodium), diuretics (like pamabrom or caffeine), antihistamines (like pyrilamine maleate or diphenhydramine citrate), and stimulants (like caffeine or cinnamedryl). For example, Midol Complete typically contains acetaminophen, caffeine, and pyrilamine maleate. Midol Teen has contained acetaminophen and pamabrom, while older formulations included ingredients like cinnamedryl and aspirin. The drug works by targeting various symptoms through the combined actions of its active ingredients.

Brand names
MidolMidol TeenMidol CompleteMidol Extended ReliefMAXIDOLMidol PMMidol Bloat ReliefMidol Complete Caffeine Free
02

Targets

HRH1 (Histamine H1 Receptor)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)TRPV1 (Transient receptor potential cation channel subfamily V member 1)

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