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MIF siRNA
- Development stage
- Preclinical
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous, Local Injection, Topical
01
Overview
MIF siRNA is a small interfering RNA molecule specifically designed to silence the gene expression of **macrophage migration inhibitory factor (MIF)**, a pleiotropic cytokine involved in immune regulation, inflammation, and cancer biology. MIF siRNA functions by binding to MIF mRNA in the cytoplasm and facilitating its degradation via the RNA interference (RNAi) pathway, thereby reducing both intracellular and extracellular MIF protein levels. This targeted gene knockdown approach is typically used in preclinical research to study the effects of MIF silencing in diseases such as cancer, inflammation, and neurological injuries. MIF siRNA has been delivered in various nanoparticle formulations for targeted delivery to cell types like macrophages and has shown efficacy in reducing MIF expression, leading to downstream effects such as inhibition of tumor cell proliferation and modulation of inflammatory responses[2][4][6].
- Other names
- macrophage migration inhibitory factor siRNAsiMIFsiRNA targeting MIFMIF-specific siRNA
02
Targets
Macrophage migration inhibitory factor mRNA
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