mifepristone + nab-paclitaxel

This combination involves **mifepristone**, a glucocorticoid receptor antagonist, and **nab-paclitaxel**, an albumin-bound form of paclitaxel used in chemotherapy. Mifepristone is used to block glucocorticoid receptor activity, which may enhance the efficacy of chemotherapy by reducing anti-apoptotic signals. Nab-paclitaxel is a taxane that disrupts microtubule function, leading to cell cycle arrest and apoptosis in cancer cells. The combination is being investigated for its potential to improve outcomes in advanced triple-negative breast cancer (TNBC) by overcoming chemoresistance mediated by glucocorticoid receptor activity.