Drug intelligence / Profile preview

miglitol

Development stage
Approved
Lead developer
Bayer
Modality
Small Molecules
Administration
Oral
01

Overview

Miglitol is an oral alpha-glucosidase inhibitor used in the treatment of type 2 diabetes. It works by reversibly inhibiting alpha-glucosidase enzymes in the small intestine, which delays the digestion of complex carbohydrates and subsequently reduces postprandial glucose levels. Approved for clinical use since 1998 (in some countries earlier), miglitol has demonstrated efficacy in improving glycemic control, reducing HbA1c levels, and decreasing both fasting and postprandial plasma glucose concentrations. Recent studies suggest potential anti-obesity effects due to activation of brown adipose tissue and increased energy expenditure. The drug is generally well-tolerated; common side effects are gastrointestinal disturbances that tend to decrease over time[1][3][6].

Brand names
GlysetDiastabolMiglibay
Other names
米格列醇 (Chinese)N-(b-Hydroxyethyl)-1-deoxynojirimycinMiglitolum
02

Targets

Sucrase-IsomaltaseGut bacterial alpha-glucosidase

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