Drug intelligence / Profile preview

Milgamma + Milgamma compositum

Development stage
Unknown
Lead developer
Wörwag Pharma
Modality
Small Molecules
Administration
Intramuscular, Oral
01

Overview

Milgamma + Milgamma compositum is a **step-therapy combination** involving two related vitamin B complex pharmaceutical formulations primarily used to address acute non-specific low back pain and various neurological systemic diseases related to vitamin B deficiencies. The therapy consists of initial intramuscular injections of Milgamma (containing thiamine hydrochloride [vitamin B1], pyridoxine hydrochloride [vitamin B6], cyanocobalamin [vitamin B12], and lidocaine hydrochloride as a local anesthetic), followed by oral administration of Milgamma compositum (containing benfotiamine—a lipid-soluble, high-bioavailability vitamin B1 derivative—and pyridoxine hydrochloride [vitamin B6]) for continued therapy[2][4]. Both forms act primarily through neurotropic mechanisms: replenishing B vitamin levels essential for healthy nerve function, myelin sheath maintenance, and neuronal metabolism. Lidocaine in the injectable Milgamma formulation provides local anesthetic and analgesic effects. The combination is used to improve pain outcomes and reduce dependence on NSAIDs in acute non-specific low back pain[2][4].

Other names
vitamin B complex with lidocainebenfotiamine + pyridoxine hydrochloride
02

Targets

BCKDHB (2-oxoisovalerate dehydrogenase subunit beta, mitochondrial)

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