milrinone

Milrinone is a small molecule, non-digitalis, non-catecholamine inotropic agent and vasodilator used primarily for the short-term intravenous treatment of acute decompensated heart failure. It acts as a selective phosphodiesterase 3 (PDE3) inhibitor, increasing intracellular cyclic adenosine monophosphate (cAMP) levels in cardiac and vascular smooth muscle cells. This leads to enhanced myocardial contractility (positive inotropy), improved ventricular relaxation (lusitropy), and vasodilation by reducing both preload and afterload. Milrinone is structurally related to amrinone but is more potent with fewer side effects such as thrombocytopenia. Its onset of action is rapid when administered intravenously, with effects peaking within hours and lasting several hours due to its short half-life[1][5][6][7][8].

Brand names

Primacor鲁南力康

Other names

米力农Milrinone Injection米利酮二联吡啶酮甲氰吡酮